TreeLD 1.0

released January 2005

The package TreeLD is a free software tool for mapping complex trait loci. TreeLD performs a multipoint LD-analysis by inferring the ancestry of a genomic region and analyzing this ancestry for signals of disease mutations. The generated likelihoods can be used to test for the presence of a disease locus and to fine-map its location, providing a point estimate and a credible region. Furthermore, the package provides a novel way of visualizing the association signal in a sample. TreeLD is designed for high-density SNP haplotypes and can be applied to case-control data, TDT trio data and quantitative trait data.

The package has a user friendly point and click interface, allowing an in depth exploration of the data.

The methods in this program are detailed in Zollner and Pritchard (2005).

Registration

We ask that you fill out a web form to register software downloads. Executables are currently available for the following platforms.

Package download:

For UNIX: [Sun], and [Linux].

For Windows 95/98/NT/2000/XP : [Windows].

Additional program

PH2TM.pl : A perl script that reformats the output of PHASE 2.1 into the input format for TreeLD.

Documentation

Documentation is included in the packages, but can be downloaded directly from here.
It is also available online.

Click here for installation instructions.

Please contact us to report any bugs or other problems at 
treeldhelp@bsd.uchicago.edu or to
Sebastian Zollner, now at szoellne@umich.edu.